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Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.

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Caution is advised in those who have cardiovascular disease.

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In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.

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Asked 2 Jun 2012 by Joseph-John Active. U.S. men seeking a generic version of Viagra.What links here Related changes Upload file Special pages Permanent link Page information Wikidata item Cite this page.Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

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Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.

There may be a generic version of viagra available in another country but there is no way to know if you are.The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.It requires vision, leadership and talented people to make it all happen.

There are also mouth spray preparations of sildenafil for faster.

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Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection.

Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store.

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Common side effects include headaches and heartburn, as well as flushed skin.