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Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine. 11 DESCRIPTION VIAGRA (sildenafil citrate), an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).During 3 to 6 months of double-blind treatment or longer-term (1 year), open-label studies, few patients withdrew from active treatment for any reason, including lack of effectiveness.However, VIAGRA may be taken anywhere from 30 minutes to 4 hours before sexual activity.

In some of the cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events.

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If VIAGRA is prescribed to patients taking ritonavir, caution should be used.Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.VIAGRA (sildenafil citrate), REVATIO (sildenafil), Cardura (doxazosin mesylate), and Minipress (prazosin HCl) are registered trademarks of Pfizer Inc.

Efficacy Results from Controlled Clinical Studies The effect on one of the major end points, maintenance of erections after penetration, is shown in Figure 6, for the pooled results of 5 fixed-dose, dose-response studies of greater than one month duration, showing response according to baseline function.Treatment with doxazosin continued for at least 7 days after dose period 1.Please see full prescribing information for VIAGRA (25 mg, 50 mg, 100 mg) tablets.

After patients have taken VIAGRA, it is unknown when nitrates, if necessary, can be safely administered.

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Do not give VIAGRA to other people, even if they have the same symptoms that you have.General information about the safe and effective use of VIAGRA.If it is not treated right away, priapism can permanently damage your penis sudden vision loss in one or both eyes.

VIAGRA may affect the way other medicines work, and other medicines may affect the way VIAGRA works, causing side effects.It requires vision, leadership and talented people to make it all happen.Studies have produced relevant data on the effects of VIAGRA on cardiac output.If you would like more information, talk with your healthcare provider.Hemic and Lymphatic: vaso-occlusive crisis: In a small, prematurely terminated study of REVATIO (sildenafil) in patients with pulmonary arterial hypertension (PAH) secondary to sickle cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported in patients who received sildenafil than in those randomized to placebo.

VIAGRA can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines.Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins.Anti-hypertensives VIAGRA has systemic vasodilatory properties and may further lower blood pressure in patients taking anti-hypertensive medications.

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Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.

A stronger CYP3A4 inhibitor such as ketoconazole or itraconazole could be expected to have greater effect than that seen with saquinavir.LAB-0220-10.0 1 The other brands listed are trademarks of their respective owners and are not trademarks of Pfizer Inc.Both sildenafil and the metabolite have terminal half lives of about 4 hours.

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Mean sildenafil plasma concentrations measured after the administration of a single oral dose of 100 mg to healthy male volunteers is depicted below: Figure 5: Mean Sildenafil Plasma Concentrations in Healthy Male Volunteers.Skin and Appendages: urticaria, herpes simplex, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis.Pfizer accepts no responsibility or liability for the content or services of other websites.For more information, ask your healthcare provider or pharmacist.